A short report from Szabadfi et al. demonstrated that urocortin 2, a corticotropin-releasing factor (CRF) paralog activating CRF2 receptors, had protective effects against retinal degeneration (preservation of retinal thickness and protection of retinal ganglion cells) by BCCAO in Wistar rats without the mode of action of urocortin 2, requiring further investigation [64]. Here, CRH is linked to retinal degeneration.