CASP3 and gastric cancer: In addition, LF has been shown to activate caspases-3 and -9 but not caspase-8 in leukemic and breast carcinoma cells [112,188]; caspases-3, −7, −8 and −9 in gastric cancer [113], whereas the apoptosis in B-lymphoma has been induced in a caspase-independent fashion [109].