SOX2 and cancer: To date, several tumor-associated antigens, such as WT1, SOX-2, RHAMM, PRAME, and a series of cancer/testis antigens (namely, MAGE-A1/A2/A3/A6, MAGE-C1/C2, NY-ESO-1, and Melan-A/MART-1), have also been discovered to be expressed by malignant PCs and to induce detectable T cell responses, often with remarkable killing capacity against neoplastic PCs in vitro [62,63,64,65,66,67,68,69,70,71,72,73,74,75].