To elucidate the immunoregulatory role of VEGF expressed by plasmacytoma cells, we developed a model of the MOPC 315 plasmacytoma that constitutively expresses VEGF and examined the effect of VEGF on the growth of MOPC 315 in vitro and in vivo, as well as on the development of an effective host anti-tumor immune response. Here, VEGFA is linked to neoplasm.