In a 2018 study, Chokchaiwong and colleagues investigate the ability of CoQ10 to restore mitochondrial function, and to prevent oxidative damages and NLRP3 activation in multiple acyl-CoA dehydrogenase deficiency (MADD), an autosomal recessive disorder that causes mitochondrial dysfunction [96]. This evidence concerns the gene NLRP3 and multiple acyl-CoA dehydrogenase deficiency.