PLG and blood coagulation disease: By targeting the plasminogen activation cascade (P00050), which is the primary catalyst of fibrin degradation [55], angiogenesis (P00005) [56], the vascular endothelial growth factor (VEGF) signaling pathway (P00056) [57], the PDGF signaling pathway (P00047) [58] and the TGF-β signaling pathway (P00052) [59], miR-MAK-403 could lead to coagulation disorder and exacerbate hemorrhaging while impairing host defenses.