Mice lacking Tet2 exhibit increased IFN-stimulated gene induction in the bone marrow myeloid progenitors after MI, consistent with a study showing that hematopoietic loss of Tet2 is associated with adverse cardiac remodeling as a result of activated NLRP3 inflammasome and overproduction of IL-1β in a murine model of MI [58]. This evidence concerns the gene TET2 and myocardial infarction.