Previous PD animal model studies have reported dysregulated interactions between SFPQ/PSF and LIM homeobox transcription factor 1 beta (Lmx1b)/nuclear receptor-related 1 protein (Nurr1), which results in metabolic impairment, α-syn inclusions, and progressive loss of dopaminergic neurons [34,35]. This evidence concerns the gene LMX1B and Parkinson disease.