Additionally, disrupted interactions between SFPQ/PSF and fused in sarcoma (FUS) has been shown in post mortem frontotemporal lobar degeneration (FTLD) brains and were associated with increased 4-repeat tau (4R-T) to 3-repeat tau (3R-T) ratios and underlying FTLD phenotype development. Here, MAPT is linked to frontotemporal dementia.