The PD-DLPFC was characterised by alterations of SNARE proteins (VAMP2 and STX1A) which negatively affect neurotransmitter release at the axon terminal, while AD-BA9 was characterised by changes in ‘nervous system development’ and MEF2C, a transcription factor, potentially inducing microglia activation. The gene discussed is VAMP2; the disease is Alzheimer disease.