In this context, obesity-related inflammation may contribute to leptin resistance, which in turn further increases weight gain [71] and leptin levels, which then increases the inflammation-related obesity, since leptin is an important proinflammatory adipokine [72,73,74], activating monocytes [75] and lymphocytes [76]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.