GPER1 and neoplasm: Likewise, in endometrial cancer reports on a decreased GPER expression relative to normal tissue and on a GPER-mediated inhibition of tumour cell proliferation [89,90] contrast with other studies showing an increased presence of the receptor in tumours, a rise in expression with increased grading and staging, poor survival among patients with high GPER expression, and an increase in the growth of endometrial cancer cell lines after GPER stimulation [91,92,93,94].