To add a novel piece to the understanding of cohesins in cancer predisposition, we analyzed whole exome sequencing data of an unselected German parent–child cohort of children with cancer (n = 60, TRIO-DD), as well as a recently published parent–child pediatric cancer cohort (n = 158, TRIO-D) [23] for germline variants in cohesin complex genes (Supplementary Table S1). This evidence concerns the gene TRIO and cancer.