In the present review of the literature, we highlight multiple mechanisms implicating the EPH/ephrin signaling pathway in bone (osteosarcoma, chondrosarcoma, Ewing’s sarcoma) and soft tissue sarcomas (synovial sarcoma, rhabdomyosarcoma) based on published in vitro and in vivo studies. This evidence concerns the gene EPHA1 and synovial sarcoma.