Among others, one of the synergistic antitumor activities that pazopanib and trametinib (receptor tyrosine kinase inhibitors) exhibit in osteosarcoma cells is carried out through the down-modulation of EPHA2 and Interleukin (IL)-7 Receptor (IL-7R), according to the in vitro findings by Chiabotto et al. [19]. The gene discussed is EPHA2; the disease is osteosarcoma.