A recent assessment found low levels of proteins playing key roles in neuronal development (complement proteins, semaphorin-7A, reelin, neural cell adhesion molecules, inter-α-trypsin inhibitor heavy chain H2, transforming growth factor β-1, follistatin-related protein 1, malate dehydrogenase 1 cytoplasmic, plasma retinol-binding protein, biotinidase, and transferrin) in MS patients compared to controls [134]. Here, CHL1 is linked to myeloid sarcoma.