Additionally in 2009, Jain et al. found evidence in EAE mice that proteolysis may be an important process in the pathogenesis of MS, implicating the role of several proteases (and their dysfunction) (α1-B-glycoprotein, β2-microglobulin, neurofilament light polypeptide and sulfated glycoprotein 1) in the pathogenesis of the disease [105]. This evidence concerns the gene HLA-G and myeloid sarcoma.