The proportions of CD8+ T cells and FCGR3A+ monocytes were significantly increased in RA group compared to HC group (p-value = 0.048; p-value = 0.005) and the proportion of CD4+ T cells was significantly decreased in SLE group compared to HC group (p-value = 0.003). The gene discussed is CD4; the disease is systemic lupus erythematosus.