The proportions of IGHJ2, IGHV1-18, IGHV3-9, IGHV2-5, IGHV3-74, IGHV5-51, IGHV3-53, IGHV3-33, IGHV1-46, IGHV7-4-1, IGHV1-8 and IGHV2-70 were higher in SLE group than in RA group, while the proportions of IGHV3-30, IGHV3-13 and IGHV4-30-4 were lower in SLE group than in RA group. This evidence concerns the gene IGHJ2 and systemic lupus erythematosus.