The proportions of IGHJ6, IGHV2-5, IGHV3-53, IGHV3-33, IGHV7-4-1, IGHV3-66 and IGHV2-26 in SLE group were higher than those in HC group, while the proportion of IGHV3-41 showed a significant decrease in SLE group compared with HC group. Here, IGHJ6 is linked to systemic lupus erythematosus.