When comparing RA group and HC group, we identified 23 differentially expressed genes for CD4+ T cells, 28 for CD8+ T cells, 35 for CD14+ monocytes, 27 for FCGR3A+ monocytes, 70 for natural killer cells, 38 for B cells and 33 for dendritic cells (Supplementary Table S5). This evidence concerns the gene CD4 and rheumatoid arthritis.