As shown in Figure 4, the rate of both the FGFR3 and p53 high expression groups gradually increased as it progressed to muscle-invasive status (UTUC tumor origin: 17.3% non-muscle-invasive IVR: 6.6%, and muscle-invasive IVR: 27.8%; Figure 4a). This evidence concerns the gene FGFR3 and neoplasm.