miR-206-3p is involved in the phosphoinositide 3-kinase and protein kinase B (PI3K–AKT) pathway by regulating insulin-like growth factor 1 (Igf1), which has a role in maintaining plaque stability, and miR-322-5p interacts with mitogen-activated protein kinase 8 (MAPK8), whose loss accelerates the onset of early atherosclerosis [79]. Here, IGF1 is linked to atherosclerosis.