A relationship between circulating EVs and inflammation has been found also in other studies: in particular, both endothelial-derived EVs [38] and circulating exosomes [39] were significantly and positively correlated with blood levels of interleukin-6 (IL-6), that is involved in atherothrombotic risk both in general population and in COPD patients, in which IL-6 represents a well-known marker of systemic inflammation [40,41]. Here, IL6 is linked to chronic obstructive pulmonary disease.