Increased levels of EVs derived from T cell could be caused by the activation of CD4+/CD8+ T lymphocytes that already exist in the airways, or by the accumulation of up-regulated CD4+/CD8+ cells, recruited during the development of COPD, suggesting that also these subtypes of EVs could be considered putative biomarkers to distinguish different types of inflammation. Here, CD8A is linked to chronic obstructive pulmonary disease.