RSPH6A is a testis-specific protein that localizes specifically in the tail of mature SPZ; we demonstrated that the expression and localization of RSPH6A in SPZ samples coming from patients affected by myotonic dystrophy type 1, a degenerative pathology of the muscular tissue associated to reproductive disorders, was lower as compared to those of normosperm [47]. This evidence concerns the gene RSPH6A and myotonic dystrophy type 1.