Accordingly, the study included 10 individuals investigated for hypercortisolism (Cushing’s syndrome) using the low-dose dexamethasone test and 10 patients tested for adrenal insufficiency or late onset congenital adrenal hyperplasia (21-hydroxylase deficiency) using the ACTH (tetracosactide) test. The gene discussed is POMC; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.