Finally, in a single-arm study of the effects of a 4-week treatment with ipragliflozin followed by a 1-week washout, in Japanese individuals with T2D, the insulin secretion/insulin resistance index significantly increased not only after the treatment for 4 weeks but also after a subsequent washout for 1 week compared with that before the treatment [70]. The gene discussed is INS; the disease is type 2 diabetes mellitus.