In a smaller clinical trial, a single dose of ianalumab (anti-BAFFR) in pSS patients also showed positive effects on ESSDAI [48], and a larger and more recent phase IIb clinical trial with ianalumab again reported a dose-dependent amelioration of disease, as measured by decreases in ESSDAI score [49]. The gene discussed is TNFRSF13C; the disease is peeling skin syndrome.