ADAMTS2 and neoplasm: By contrast, ADAMTS2 overexpression has been linked to an increased incidence of some forms of gastric [50] and oral cancers [51,52], possibly suggesting that longer LOX-PP isoforms containing sulfated tyrosine residues resulting from ADAMTS 2 or 14 cleavage only, should they accumulate, may reduce the tumor suppressor functions of LOX-PP and/or increase LOX enzyme tumor promoting effects.