Hu et al. [34] subsequently demonstrated that SecinH3 also has protective effects against neurotoxicity induced by expression of mutant TDP-43 (TDP-43Q331K), which is associated with ALS and frontotemporal dementia (FTD), by reducing ER stress-mediated apoptosis and promoting the autophagic flux in SH-SY5Y cells, a human neuroblastoma cell line. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.