The density profile of DELs in mCRC is distinct from those in metastatic breast- and prostate-cancer but bears resemblance to a profile seen in, e.g., primary esophagus and pancreas cancer [10], with the top affected CFS loci and their connected genes (FHIT, MACROD2 and WWOX) also among the reported regions here. Here, WWOX is linked to pancreatic neoplasm.