Both Mgat5−/−:Npc1−/− (n = 9) and Mgat5+/+:Npc1−/− (n = 5) mice exhibited generally elevated levels of these enzymes in their serum compared to the control mice (Mgat5+/+:Npc1+/+ (n = 8), and Mgat5−/−:Npc1+/+ (n = 10)), suggestive of liver disease in both groups at this age (Figure 6). Here, NPC1 is linked to liver disorder.