CXCL2 and acne: All these genes encode proinflammatory cytokines and chemokines previously detected in acne lesions [58] and are linked to activation of the NF-κB pathway, inducing the upregulation of TNF-α, CXCL8/IL-8, IL-1β, CXCL1 and CXCL2 [16,59,60].