Remarkably, in a pilot study involving 20 AD patients, PBMC expression of miR-7-5p and miR-223-3p was higher in tandem with increased activation of the NLRP3 inflammasome, suggesting that these miRNAs may be overexpressed in AD in a vain effort to suppress NLRP3 signaling, possibly implying that the brake of these molecules on NLRP3 is compromised in AD [89]. This evidence concerns the gene NLRP3 and Alzheimer disease.