NLRP3 and Alzheimer disease: In a transgenic mouse model of AD, NLRP3 or caspase-1 knockdown prevented spatial-memory impairments and decreased brain concentrations of caspase-1 and IL-1β, while increasing microglial phagocytosis able to remove Aβ, suggesting a role of NLRP3 inflammasome in the pathogenesis of AD.