This study confirms the anti-human colon cancer activity of DET in vivo and in vitro and elucidates that DET can induce apoptosis of colon cancer by the miR-205-Bcl2 axis, as well as enhance the chemosensitivity of 5FU to colon cancer, which has a bright prospect for the treatment of colon cancer patients. Here, BCL2 is linked to colonic neoplasm.