It was surprising to see that in the transformed cervical keratinocytes from healthy tissue in the direction of malignant development, the expression of ERα was gradually lost, and in mature cancer, no ERα expression could be detected, while, in contrast, the expression of ERβ was preserved and both ERα and ERβ expression were determined in the surrounding stroma [238,239,240,241,242,243]. Here, ESR2 is linked to cancer.