Granzyme B and perforin are thus important for both the clearance of the malignant transformed tissue and its progression in vivo, and help to determine whether the pro- or anti-tumorigenic forces of the immune microenvironment fight for dominance within the cervical intraepithelial lesions and the tumor and its microenvironment prevail [255,256,257,258,259,260]. The gene discussed is PRF1; the disease is neoplasm.