PDE3A and cancer: The latter pathway, at high hormone concentrations, via estradiol-induced phosphodiesterase 3A (PDE3A) activation and transactivation of Schlafen, a family member 12 (SLFN12) protein that is predicted to act upstream or within the negative regulation of cell proliferation, leads to the inhibition of mitochondrial activity and the blockade of the apoptotic proteins Bcl2 and Mcl1 for cancer cell apoptosis [232].