AKR1B10 and chronic kidney disease: Plasma levels of AKR1B10 were not different among the 3 CKD category subgroups (CKD stages 1–2, CKD stage 3, and CKD stages 4–5; Figure 5A), whereas plasma AKR1B10 levels showed increasing patterns with higher levels of HSI and FIB-4 categories (Figure 5B,C).