To see whether plasma AKR1B10 is still a good biomarker of NASH and fibrosis, independent of obesity, insulin resistance, and other parameters, we performed multiple logistic regression analysis against the outcomes, having age, sex, BMI, HOMA-IR, ALT, MRI-PDFF, and AKR1B10 (log-transformed) as covariates. The gene discussed is GPT; the disease is obesity due to melanocortin 4 receptor deficiency.