Interestingly, our results show that two subunits comprising the non-erythroid spectrin, also known as non-erythroid fodrin (αIIβII), including the αII subunit (SPTAN1,) also called αII-spectrin and which is known to be the non-erythroid homolog of αI-spectrin, more commonly referred to as α-fodrin, and the βII subunit (SPTBN1), more commonly referred to as β-fodrin, were up-regulated in lung fibroblast cell lines with IPF phenotype when compared to normal lung fibroblasts [53]. The gene discussed is SPTBN1; the disease is idiopathic pulmonary fibrosis.