NT5E and Hepatic fibrosis: For example, in models of liver fibrosis induced by carbon tetrachloride (CCl4) or thioacetamide (TAA) in CD73 knockout mice (CD73KO) and wild-type C57BL/6 control mice (WT), it was shown that CD73KO mice developed a lower degree of fibrosis accompanied by a lower collagen content when compared in the livers of WT mice after treatment with CCl4 or TAA [45].