Other studies in a murine model of bleomycin-induced IPF have shown that Thy-1−/− mice develop more severe pulmonary fibrosis, accompanied by an increase in TGF-β activity and a significant increase in collagen accumulation at 14 days after bleomycin treatment when compared to WT mice [36]. The gene discussed is TGFB1; the disease is idiopathic pulmonary fibrosis.