IGKV2D-29 and multiple sclerosis: Adenosine 2A receptors (A2A) are G-protein-coupled receptors targeted by CNS neurotransmitters and highly implicated in multiple neurological disorders [268], such as schizophrenia, bipolar disorder, HD, PD, preclinical models of AD, addiction, aging, epilepsy, and multiple sclerosis [269,270].