PPM1D and diffuse intrinsic pontine glioma: For example, in diffuse intrinsic pontine gliomas (DOPGs) where p53 is dysregulated by Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) gain-of-function mutations [129], the Idasanutlin has been shown to selectively inhibit the proliferation of the TP53 wild-type/PPM1D mutant DIPG cell lines in a dose- and time-dependent manner.