In this CCM model, Ccm-floxed mice are crossed with CreERT2 mouse lines, such as Pdgfb-CreERT2 or Cdh5(PAC)-CreERT2 mice for endothelial-specific CCM loss and Slco1c1(BAC)-CreERT2 or Mfsd2aCreERT2 mice for brain endothelial-specific CCM loss [53,96,97,98]. This evidence concerns the gene CDH5 and cerebral cavernous malformation.