PDCD10 and cerebral cavernous malformation: Inducible CCM models develop CCM lesions sharing similarities with human CCM lesions; for example, endothelial cell-specific CCM3 deletion at P1 results in CCM lesions with hemosiderin deposits (a marker of cerebral hemorrhage), lack of pericytes and astrocytic foot processes, and mononuclear inflammatory cell infiltrates [53].