A recent study examining reactive astrocyte signatures in neuroinflammation showed the presence of A1 astrocyte phenotype activated by microglia-derived IL-1α, TNF, and complement component 1q (C1q) in the different brain regions of AD, PD, ALS, MS, and HD patients and animal models [76]. The gene discussed is IL1A; the disease is amyotrophic lateral sclerosis.