When we grouped the commensal and clinical isolates based on their isolation source, we observed that proteinase-3 was the neutrophils’ enzyme that induced biofilm formation (proteinase-3-induced biofilm) in most of the isolates from healthy conjunctiva (HC), healthy skin (HS), ocular infection (OI), and prosthetic joint infection (PJI) (p < 0.05 for isolates of HC; Table 3). The gene discussed is PRTN3; the disease is osteogenesis imperfecta.