The caspase-11 non-canonical inflammasome induces GSDMD-mediated pyroptosis and the secretion of pro-inflammatory cytokines, and caspase-11 non-canonical inflammasome-induced pyroptosis and pro-inflammatory cytokine secretion are independent of the canonical inflammasomes, which strongly suggests that the caspase-11 non-canonical inflammasome could be an independent therapeutic target of inflammatory liver diseases. The gene discussed is GSDMD; the disease is liver disorder.