Several studies have demonstrated that canonical inflammasomes, particularly NLRP3 inflammasomes, are key players in numerous inflammatory diseases [10,11], and sufficient evidence has demonstrated that canonical inflammasomes play critical roles in the pathogenesis of inflammatory liver diseases, such as NAFLD, NASH, and inflammatory liver injury [14,15,16]. This evidence concerns the gene NLRP3 and metabolic dysfunction-associated steatohepatitis.