GSDMD and metabolic dysfunction-associated steatohepatitis: Interestingly, recent studies have also investigated the regulatory role of the caspase-11 non-canonical inflammasome in the pathogenesis of inflammatory liver diseases, which suggests that the caspase-11 non-canonical inflammasome is a key player in NAFLD, NASH, and liver diseases caused by inducing hepatic inflammation and GSDMD-dependent pyroptosis.