Thus, a blockade of the BDNF-TrkB signaling pathway by the TrkB inhibitor ANA-12 can abolish the protective effect of sEH gene deletion in the middle cerebral arterial occlusion (MCAO) models of stroke [126], suggesting the role of BDNF-TrkB signaling in the actions of sEH inhibitors. Here, BDNF is linked to stroke disorder.