Interestingly, treatment with t-AUCB (a sEH inhibitor) after ischemic stroke onset has been shown to exert brain protection in a sample of non-diabetic mice, but not in type 2 diabetes mellitus (DM2) mice, while DM2-induced hyperglycemia can abolish t-AUCB-mediated neuroprotection against stroke [132]. Here, EPHX2 is linked to ischemic stroke.