Among the host splicing factors facilitating the regulation of HPV16 and HPV18 RNA splicing, SRSF3 (SRp20) is perhaps the most remarkable host splicing factor, which not only regulates the early-to-late switch of HPV16 and HPV18 productive infection, but also prevents keratinocyte differentiation [56,79]. This evidence concerns the gene SRSF3 and infection.