Although GRα is the classic GR isoform—binding glucocorticoids and activating transcription of glucocorticoid receptor element-containing genes—GRβ has shown important implications in inflammation and diseases like rheumatoid arthritis, asthma, and glioma [7,8,9], but the independent roles of GRα and GRβ isoforms have not yet been investigated in epilepsy. The gene discussed is GZMB; the disease is central nervous system cancer.