GDNF and Alzheimer disease: Nano-formulated rosiglitazone, for instance, has a neuroprotective effect lowering the levels of TNF-α and IL-6, upper regulating important neurogenesis growth factors, such as BNDF, glial cell line-derived neurotrophic factor (GDNF), and NGF, also improving memory and learning functions in a mice model of Alzheimer’s disease [98].