CYCS and neuroblastoma: Interestingly, it has been demonstrated that after the differentiation of a mouse neuroblastoma cell-line Neuro2a (N2a) toward neurons and differentiation of the 3T3L1 cell-line into adipocytes, Raman spectroscopy detected an increased amount of cytochrome c in the cytosol in both cell lines [121], indicating that cytochrome c detection also may be dependent on differentiation status.