The inhibition of MSH6 expression was observed in the ascending colon of PSC patients with concurrent UC (0.7 ± 0.3 vs. 1.2 ± 0.2 in controls, p = 0.01), whereas downregulation of MLH1 mRNA was observed in the ascending colon of PSC patients (0.8 ± 0.1 vs. 1.1 ± 0.1 in controls, p = 0.02). The gene discussed is MSH6; the disease is pancreatic serous cystadenoma.