In lupus-prone mouse strains, the upregulation of MIF and CD74 was also positively correlated with worsening renal inflammation, whereas lupus mice lacking the MIF or CD74 receptor are protected from LN, demonstrating the role of the MIF-CD74 axis in the pathogenesis of LN [59,60]. The gene discussed is MIF; the disease is systemic lupus erythematosus.