MIF and obesity due to melanocortin 4 receptor deficiency: Therefore, MIF contributes to the pathogenesis of many immune and autoinflammatory diseases including sepsis [5], atherosclerosis and cardiovascular disease [6,7,8], rheumatic arthritis (RA) and systemic lupus erythematosus (SLE) [9], gastric and liver inflammation [10,11], neuroinflammation [12], obesity and diabetes [13], and kidney diseases [14,15].