In addition, anakinra suppressed the expression of inflammatory biomarkers, such as IL-6, MMP-9, and MCP-1 in HUVEC, RAOSMC, and 3T3-L1 adipocytes, suggesting that anakinra treatment could be a useful strategy for blocking the inflammatory signals mediating the process of atherosclerosis and systematic inflammation. Here, CCL2 is linked to atherosclerosis.