However, a recent experiment on the neutralization of two IL-1 isoforms showed different roles of IL-1α and IL-1β according to the stage of atherosclerosis in mice; IL-1α blockade affected the vascular remodeling during early atherosclerosis, but IL-1β blockade modulated inflammatory processes and reduced the extent of atheromatous plaque [27]. Here, IL1A is linked to atherosclerosis.