While we show the powerfulness of trappc9-deficient mice in investigating obesity development and uncover several cellular pathways that are perturbed by the deficiency of trappc9 in mice, our study is limited in exploring the molecular underpinnings behind the perturbation of these pathways and lacks attempts to examine whether the perturbation can be attenuated upon restoring trappc9. The gene discussed is TRAPPC9; the disease is obesity disorder.