INS and type 1 diabetes mellitus: In a recent study, ~1 μm phagocytosable polylactic acid-glycolic acid ethanol (PLGA) microparticles (MPs) (Figure 3) were used to deliver tolerance-promoting factors such as vitamin D3, TGF-β1, GM-CSF, and T1D-specific autoantigen insulin to DCs to reprogram autoimmune responses and prevent autoimmunity [135].