IL6 and primary biliary cholangitis: While the small sample size (3 MZ twins) prevents firm conclusions and might suggest that observed differences could be due to randomness, it is still interesting to notice that 14 out of 60 genes were also differentially expressed between PBC cases and controls and involved pathways potentially linked with PBC pathogenesis, such as IFN-associated proteins or Interleukin 6 [23].