The second mRNA coexpression network associated with chemotherapy resistance in our HGSOC cohort that replicated in the AOCS (darkolivegreen) included genes associated with fatty-acid metabolism (SREBF1, ACAA1, ACADVL), and the protein kinase B oncogene (AKT1), which promotes de novo lipid biosynthesis in cancer [54]. This evidence concerns the gene AKT1 and cancer.