RORC and psoriasis: It has also been reported that H3K27 demethylation, via Jmjd3, regulates Th17 cell differentiation and expression of several inflammatory cytokines, establishing a pathogenetic role for this epigenetic mechanism in psoriasis; indeed, Jmjd3 directly bound to and reduced H3K27 trimethylation levels in the genomic region of Rorc (RAR related orphan receptor C), which encodes the master Th17 transcription factor Rorγt and Th17 cytokine genes such as IL-17, IL-17f, and IL-22 [88].