The Jumonji domain-containing protein-3 (JMJD3), also known as lysine-specific demethylase 6B (KDM6B), is a histone demethylase that regulates the trimethylation of histone H3 on lysine 27 (H3K27me3), and it has been studied extensively in immune diseases, cancer, and tumor development [44]. Here, KDM6B is linked to immune system disorder.