FLG and atopic eczema: Finally, a study investigating the relationship between genetic and epigenetic changes in the filaggrin (FLG) gene—essential for the regulation of epidermal homeostasis—in PBMCs of patients with atopic dermatitis, indicated that the association between loss-of-function mutations in the FLG gene and eczema was orchestrated by DNA methylation; in particular, at an 86% methylation level, filaggrin haploinsufficient subjects had about a 6-fold increased risk of eczema when compared to those with wild type FLG [112].